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Its supporting evidence is animal and cell-culture research, which is genuinely interesting for understanding mechanism but doesn't establish human safety or efficacy at any particular dose

It does tend to dry out the skin, so its important to follow up with a moisturizer after using it and to wear sunscreen with at least SPF 50

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These investigations led to the discovery of at least 30 genes named autophagy-related genes (Atg) that are essential for the execution of each step of the autophagic pathway (Ravikumar et al., 2009)