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From a mechanistic perspective, these outcomes are mediated by multi-system endocrine adaptations, including suppression of the HPG axis, alterations in insulin and glucose-regulating hormones, reduced triiodothyronine (T3), elevated cortisol, and disruptions in growth hormone (GH) and insulin-like growth factor 1 (IGF-1) signaling [92]

Increased amounts of methemoglobin ( 67 ), hemichromes ( 68 ), and denatured hemoglobin (Heinz bodies) ( 68 , 69 ) and increased thiobarbituric acid-reactive substances ( 70 , 71 ), an indicator of lipid peroxidation, all have been reported as evidence of oxidation damage in high-density red cells

Es un pptido, una pequea protena que se produce naturalmente en cada clula del cuerpo