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The underreported symptoms are leads that came from patients themselves, unprompted, and clinicians could potentially pay attention to them. Clinical trials generally identify the most dangerous side effects of drugs, adds Lyle Ungar, Professor in CIS and a co-author on the study

The data suggest that the decrease in lean mass is comparable to that seen with bariatric surgery, and exercise capacity generally improves following bariatric surgery (76)

The SGLT2i anti-hyperglycemic agents influence fasting as well as the postprandial components of glycaemia, and DPP4i anti-hyperglycemicagents have more prominent effects on postprandial hyperglycemia

Furthermore, irrespective of the importance of these outcomes, the outcomes of quality of life of subjects with PD, non-motor symptoms, and required daily doses of medications were considered to be of clinical importance for them to maintain a more convenient life with fewer drug side effects