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Hsieh, J

This has even been achieved in lower eukaryotes such as Saccharomyces cerevisiae , where a significant resistance to chlorambucil and doxorubicin (eight- and 16-fold, respectively) was reported in cells transfected with mammalian GST isozymes (Black et al ., 1990)

Response: We note that many of the factors recommended are provider-level characteristics, and as such are not feasible to use as a patient characteristic for stratification

Viscosity is a critical quality attribute because it directly affects pump performance (higher viscosity requires more force to actuate), valve function, and droplet size distribution (more viscous formulations tend to produce larger droplets with reduced aerosol fineness)