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[DOI] [PMC free article] [PubMed] [Google Scholar] 79.Flieger J., Flieger W., Baj J., Maciejewski R
Phosphoproteomics results were normalized to the total proteomics
Several examples have also now emerged suggesting the GH/IGF-1 signaling pathway is relevant to human aging 12 , including the discovery of functional mutations in the IGF-1R gene in individuals with exceptional longevity, resulting in relative IGF-1 resistance 13,14 , and in subjects lacking functional GH receptors (Laron dwarfs) 15