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N-terminal acetylation, the Nle 4 substitution (methionine replaced by norleucine, oxidation-resistant), the D-Phe 7 substitution (stereochemical inversion resistant to proteolysis) and lactam cyclization are the four pharmacochemical innovations that transform alpha-MSH's 2-5 minute half-life into a multi-hour half-life

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Proc Management Periop Comp Gastrointest Surg, 1994

While the endonucleases can cut at different points along the polynucleotide strand, either single-strand or double-strand breaks, there exist exonucleases-which cleave nucleic acids from the ends, either 5 or 3 (92)