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these cytokines are produced primarily by adipocytes, tissue-resident macrophages, and infiltrating immune cells (e.g., Th17 cells and other T lymphocytes) within the adipose tissue, which can exacerbate keratinocyte activation and immune dysregulation in psoriatic skin (48)

In general, our results showed that ethanol exposure may reduce the antioxidant capacity in the hippocampal of WT mice, leading to the occurrence of neuroinflammation, while in APP/PS1 mice, ethanol exposure further worsened this process by exacerbating the pathological progression of AD

To mitigate the risk of receptor desensitization, experts suggest a one to three-week washout period following a 14-day course of Selank [20]