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Cellular senescence: a key therapeutic target in aging and diseases

That mechanism was validated at meaningful scale: the pivotal trial program supporting FDA approval enrolled 816 HIV-infected adults with clinically defined lipodystrophy, one of the larger controlled datasets behind any peptide discussed in this category

Besides contributing to the increase of tumour mass, the rewiring of cholesterol and sphingolipids metabolism alters the composition of lipid rafts that play an important role in other hallmarks of cancer such as oncogenic signalling, migration, proliferation, adhesion, invasiveness, metastatic spread, apoptosis evasion [51], vesicular trafficking and drug resistance [52]