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Hypogonadotropic Hypogonadism For individuals with hypothalamic dysfunction, kisspeptin can restore GnRH pulsatility and may reactivate the entire reproductive axis

Conclusions Among adults with HIV on ART and lipohypertrophy, semaglutide (GLP-1) slowed DNA methylation aging across PCGrimAge, PhenoAge, DunedinPACE, and organ clocks, while IC was unchanged

Because only around 1% of an oral dose is absorbed (versus ~89% for an injection), a much larger oral dose is needed to deliver an equivalent amount of semaglutide into the bloodstream

Pfizers $4.9 B acquisition of Metsera (2025) secures MET-097i and a next-gen obesity pipeline, positioning Pfizer as a major re-entrant in metabolic disease innovation