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found that RNA binding motif protein 45 (RBM45) enhances its stability by antagonizing non-autophagy lysosomal degradation, which is also associated with the poor prognosis of hepatocellular carcinoma [48]

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The activation of NRF-2 in liver suppresses the synthesis of fatty acids [70], as observed in this study that included experimental feeding with 8-week-old NRF-2 null mice, and wild-type mice fed experimentally, observing the mRNA of sterol regulatory element-binding protein 1-c and fatty acid synthase as highly expressed in NRF-2 null [71], concluding that the protective action is afforded by the increase of AR

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