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We therefore assume that the reaction sequence for the reduction of roGFP2(S 2 ) requires at least a reorientation of the GSSR intermediate and that this may also be the case for other non-glutathione protein disulfide substrates

This simply means that supplementing with a bioavailable antioxidant can more easily satisfy the metabolic needs that depend on a supply of antioxidants, unlike dietary antioxidants which dont satisfy these metabolic needs completely (4)