glp-1 receptor agonists are contraindicated in

glp-1 receptor agonists are contraindicated in glp-1_analogs [TUSOM Frontiers | GLP-1 Receptor Agonists:

Name: glp-1 receptor agonists are contraindicated in glp-1_analogs [TUSOM Frontiers | GLP-1 Receptor Agonists:
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10.1016/j.bbagen.2012.09.008 8

Clin Exp Allergy 32:571577 Rolseth V, Djurhuus R, Svardal AM (2002) Additive toxicity of limonene and 50% oxygen and the role of glutathione in detoxification in human lung cells

These are all large, humans studies with consistent directions of effect, and Phase 3 corroboration of Phase 2 findings (for weight loss and knee osteoarthritis)

Solving that problem means creating molecules that look like GLP-1 but last longer than the natural version