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In particular, specific research lines should be created based on the peptide's action, which would validate a repeatable in vivo study in animals in order to generate repeatable clinical protocols in humans

The prominent lymphocytic inflammationat least in the earlier relapsing phase of the diseaseis traditionally thought to be the primary insult with immune cells recruited into the CNS to induce recurrent chronic injury (Box 1)

Faulty proteolysis and hindered autophagy 286 lead to the accumulation of -syn aggregates, which can trigger disease progression once they exceed a specific threshold

Accumulating evidence suggests that the regulation of ferroptosis can change the level of OS in cardiomyocytes or vascular cells, resulting in cardiomyocyte injury, cardiac hypertrophy and HF through the interaction between ROS with ERS ( In summary, CD is pivotal for internal homeostasis and prevention of CCVDs ( 3.3.4 Ferroptosis and Inflammation Inflammation is a basic pathological process including infection and tissue damage, and appears when the organism is stimulated by some specific physiological or pathological factors