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Second, the respective study populations were quite different, with STEP 1 including a younger, healthier population with more women (73.1% of the semaglutide arm in STEP 1 versus 27.7% in SELECT) and higher mean BMI (37.8 kg m 2 versus 33.3 kg m 2 , respectively) 14,21

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When combined with 5-Amino-1MQ, which inhibits NNMT (nicotinamide N-methyltransferase) to preserve NAD+ pools, the two compounds target overlapping but mechanistically distinct pathways

It is not widely available as a consumer product