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PubChem Reference: View compound profile on NIH PubChem Key Characteristics MOLECULAR PROFILE Formula: C 78 H 123 N 23 O 23 S 2 Weight: 1,815.1 g/mol CAS: 221231-10-3 Origin: Residues 177-191 + N-terminal tyrosine Size: 16 amino acids Structure: Intramolecular disulfide bridge PHYSICAL PROPERTIES Form: White to off-white lyophilized powder Solubility: Readily soluble in water

Applications received for the later deadlines for the remaining 2025 quarters (the quarters beginning June 1, September 1, and December 1 of 2025), if any, will be discussed in the CY 2027 OPPS/ASC proposed rule

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Biol Trace Elem Res 195:499505 Friedman B, Cronstein B (2019) Methotrexate mechanism in treatment of rheumatoid arthritis