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In addition, novel regulators such as RNA methylation enzymes (METTL3/14) that modulate GPX4 mRNA stability (176), or RhoA-mediated vascular remodeling that enhances iron leakage into subchondral bone (97), may offer new molecular targets

On the other hand, iron overload induced ferroptosis in foam cells which led to plaque instability, and ferroptosis in foam cells increased IL-1 and IL-8 expression, promoting inflammatory responses (Su et al., 2021)

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