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No changes were observed at low concentrations that would be related to environmental exposure

One potential mechanism is the Nrf2-ARE pathway, which induces a phase 2 detoxification response that promotes disruption of Nrf2-Keap protein interactions, translocation of Nrf2 to the nucleus, and regulation of target gene expression through the ARE, enhancing cellular defense against oxidative damage (Sharma et al., 2010)

A total of 107 women aged 4065 years were tested among four different treatment groups that received the following treatments daily: treatment 1 contained 10 g of hydrolyzed fish collagen (HFC) ( n =27), treatment 2 contained 5 g of HFC plus 1.5 g of MSM ( n = 26), treatment 3 contained 10 g of HFC plus 1.5 g of MSM ( n = 27), and treatment 4 was the placebo control ( n = 27)

KPV KPV has attracted attention in studies involving inflammatory signaling pathways and immune-related biological mechanisms