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(2009) "Heparinization" and hyperfibrinogenolysis by wasp sting
The bulky A350 6.39b W and K351 6.40b A mutants almost abolished the maximal response (Emax) of GLP-1R-mediated cAMP accumulation in presence of compound 2, while V332 5.62b A, K346 6.35b A and L349 6.38b A mutants greatly elevated basal cAMP activities but significantly diminished the efficacy of the response upon stimulation by either compound 2 or GLP-1, suggesting these mutations affect the kink of TM6 required for receptor activation
Clinical and preclinical studies report effects on oxytocin, kisspeptin, and gonadotropins that may shift libido or ovulation windows
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