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A product is not considered medical if its dose is less than what is now known to be necessary to restore, adjust, or modify a physiological function

Ex vivo bronchial biopsies derived from asthma patients and human lung fibroblasts culture in vitro demonstrated apigenin (10, 20 M) attenuates TGF- induced fibroblast-to-myofibroblast transition, in a non-cytotoxic and non-cytostatic manner, potentially correlated with the inhibition of -smooth muscle actin and tenascin C expression [141]

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The action of senomorphic drugs is based on delaying or preventing cell aging by controlling or reducing SASP [98]