Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: results of a pilot clinical trial

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In the SURMOUNT-1 trial with 2,539 participants, patients taking 15 mg tirzepatide weekly (combined with diet and exercise) lost an average of 20.9% of their body weight over 72 weeks
Firstly a treatment duration of 2 years is proposed