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The interdependency is easiest to see at the level of the mitochondria

Hypothalamic Energy Homeostasis (ARCPVN Axis) Amylin receptor signaling in the arcuate nucleus (ARC) and paraventricular nucleus (PVN) of the hypothalamus modulates neuropeptide Y (NPY), AgRP, POMC, and CART expression, intersecting with leptin and GLP-1 receptor signaling networks

Keep in mind that this choice also contains a dose of folate as 100 mcg folic acid you may typically find these two nutrients together in supplements since they work together to form healthy red blood cells

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