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The scientific community needs more data

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However, a large Taiwanese cohort study of 11.7 million obese individuals found that GLP-1 RAs, particularly semaglutide, were associated with increased risk of depression, anxiety, and suicidal behavior [10]

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Appetite suppression occurs through direct signaling to hypothalamic hunger centers in the brain

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Both tirzepatide and semaglutide are FDA-approved, have support from more long-term data, and are already used in real-life settings

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