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the fabricated patch of the transdermal delivery system containing from around 0.5 mg to 200 mg of GHK-Cu per patch intended for a 12 hrs / 24 hrs / 48 hrs /72 hrs delivery aims to provide GHK-Cu in controlled manner to provide additional 120-140 microgram/litre of GHK-Cu to obtain the drug plasma level up to 200 microgram/litre

The study also examined nuclear factor kappa B (NF-B) and Nrf2 and the expression of its down-stream target genes heme oxygenase 1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1)