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The insight that changed this view is that when glucagon receptor activation occurs alongside GLP-1 activity, the net effect is a shift toward increased energy expenditure and fat oxidation rather than hyperglycemia

Propensity scores for each outcome were calculated based on the probability of initiating treatment with GLP-1RA taking into account the same covariates, to generate patient-specific stabilised weights

Furthermore, the C-terminal Gly from the predicted sequence was used as donor for amidation of the naturally occurring human peptide

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