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A large phase clinical trial of NR has been registered on a broad range of pathologies, including infection, neoplasms, aging-related diseases and disorders that occur in the circulatory system, genitourinary system, nervous system and skin (Table 1)

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Myocardial remodelling characterized by fibrosis and hypertrophy, impaired microcirculation, abnormal protein function caused by advanced glycation end products, changes in myocardial metabolism and abnormal mitochondrial function have been noted as associated factors of diabetic cardiomyopathy [14]