A further limitation was the fact that we did not assess associations between obesity class and other adverse health impacts known to be associated with overweight status, such as lifespan, quality of life and comorbidities 2,3,4,5,6,7,8,9,10
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Thus, in a nutshell, it is possible that the initial DNA damage that predisposes melanocytes to malignant transformation and cytogenetic alterations that later promote actual malignant transformation of the initially transformed melanocytes may be driven by dysregulation in melanin biosynthesis and by the increased cellular content of melanin [10]
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