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References: Cani PD et al., 2019 Written by Ali Rza Akn Microbiome Scientist, Author & Founder of Next-Microbiome Ali Rza Akn is a microbiome scientist with nearly 30 years of experience in translational biotechnology, systems biology, and applied microbiome research, spanning discovery, preclinical development, and clinical-stage translation

Most gastrointestinal side effects are dose-dependent and tend to be most pronounced during the initial weeks of treatment or following dose escalation

Retatrutide adds a third mechanism: glucagon receptor agonism

The dual effect of appetite suppression and improved insulin sensitivity helps individuals lose weight more sustainably