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Thus, there is a growing need to implement innovative strategies for assessing drug efficacy more rapidly and with greater personalization, highlighting the urgent need for advanced in vitro models, including the immune-competent, multi-tissue RA-on-chip platforms, capable of replicating the complex interplay between immune cells and joint-resident stromal components (94, 194, 195)

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In functional medicine, they are paired with supplements like DHHB and personalized lifestyle plans to help address the root causes of cognitive decline and support long-term brain health

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