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The side effects observed were [31]: Nausea (24% of participants) Diarrhea (21%) Vomiting (14%) Constipation (8%) Dyspepsia (7%) Injection site reactions (3%) Cholelithiasis (less than 1%) Pancreatitis (less than 1%) Gastrointestinal side effects were the most common reason for discontinuation and their severity varied from mild to moderate

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A separate analysis of the STEP 1 data found that lean mass was reduced by 6.92 kg with a total weight reduction of 15.3 kg, meaning roughly 45 percent of the weight lost was lean mass

Metabolism Boost: Unlike many weight-loss drugs, Retatrutide accelerates fat burning in addition to reducing hunger