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What the study showed overall Retatrutide achieved both co-primary endpoints for weight loss and pain reduction, and key secondary endpoints related to physical function, demonstrating consistent efficacy across clinically important measures

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Many prescription GLP-1 medications used for weight management act directly as GLP-1 receptor agonists, are backed by large clinical trials, and are available only with a prescription

Factors that should alert clinicians to possible nondiabetic aetiologies include an absence of retinopathy, duration of diabetes less than five years, acute renal injury pattern of renal dysfunction rather than gradual progression, presence of haematuria or other systemic disease and presence of nephrotic syndrome (albuminuria greater than 3 g/day, low serum albumin level, oedema and symptoms such as frothy urine)