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A 2025 systematic review of BPC-157 in orthopedic sports medicine acknowledged the compelling preclinical data while noting the absence of human clinical trials as a critical limitation

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A meta-analysis of RCTs and cohort studies showed that SGLT2 inhibitors reduce the risk of AKI across diverse cardiovascular risk profiles [59,109], and are associated with lower mortality, major adverse kidney events, and MACE in acute kidney disease [110]