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El GSH, que explota el residuo tiol activo redox (-SH) de la cistena, ejerce su funcin antioxidante principalmente a travs de reacciones mediadas por glutatin peroxidasas (Gpxs), que dan como resultado un tampn de perxido con oxidacin simultnea de GSH a GSSG

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The density indicates some flexibility at R471 in both the inward-facing and ipratropium-bound structures, but both are pointing down towards the extracellular side and wedged between S157 and S467, preventing the H-bond network we observe in the occluded conformation (Fig