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"We are thrilled that today's findings showed the superior weight loss of [tirzepatide], which helped patients achieve 47% more relative weight loss compared to [semaglutide]

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The potential mechanisms underlying the increased risk of gastric aspiration are not fully understood, and nowadays it is explained mainly by delayed gastric emptying and inhibition of gastrointestinal motor function that GLP-1-RAs exert through both central motor nuclei and vagal afferents [13, 14]