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[3] [4] Ergothioneine was discovered by Charles Tanret in 1909 and named after the ergot fungus from which it was first purified, [5] with its structure being determined in 1911

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2 Epigenetic allostasis model As an inescapable factor of the natural world, stress plays a pivotal role in the adaptive and maladaptive responses to the environment through epigenetic mechanisms [1, 18]

Do redox-modulating therapies (e.g., thiamine, CoQ10, NRF2 activators, molecular hydrogen), when compared to placebo or standard care, improve pain, fatigue, sleep, or oxidative stress markers in FM