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As of September 2023 it is on the FDA's Category 2 list of bulk drug substances that may not be compounded due to significant safety risks, and the agency has scheduled a Pharmacy Compounding Advisory Committee (PCAC) review for July 2026 covering proposed uses in opioid withdrawal, chronic insomnia, and narcolepsy

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Lack of knowledge and understanding of what services were available was an additional barrier for service providers

Complications People with Barrett's esophagus have an increased risk of esophageal cancer