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Key Takeaways: Mounjaro vs Ozempic Mounjaro (tirzepatide) shows higher average weight loss: 22.5% vs 14.9% for Ozempic (semaglutide) Mounjaro acts on two receptors (GLP-1 and GIP), Ozempic acts on one (GLP-1) Both are FDA-approved for type 2 diabetes, commonly used off-label for weight loss Side effects are similar: nausea, diarrhea, constipation, though Mounjaro may cause slightly more GI issues Brand prices: Mounjaro $1,069/month, Ozempic $969/month Compounded alternatives: tirzepatide $349/month, semaglutide $199/month through TrimRx Insurance coverage inconsistent for both when used for weight loss Most people tolerate both medications well after initial adjustment period What Are Mounjaro and Ozempic

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However, avoid calcium-rich supplements within 2 hours of your dose, as they may interfere with its absorption