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In the Phase 3 ESSENCE trial for metabolic dysfunction-associated steatohepatitis (MASH), semaglutide 2.4 mg weekly produced a 28.7 percentage-point difference over placebo in MASH resolution without fibrosis worsening, and a 14.4 percentage-point difference over placebo in fibrosis improvement without MASH worsening with 32.7% of semaglutide-treated patients achieving both endpoints simultaneously

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151 Activated AKT can phosphorylate and inhibit TSC2, which regulates translation, transcription, and other cellular processes by removing the inhibition of mTORC1 by the TSC1/2 complex and promoting mTORC1 activity