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Antioxidant supplementation may support faster results, however, adding supplements at this stage may increase the complexity of the regimen, requiring patients to be diligent and consistent in their approach
Acute ischemic injury of astrocytes is mediated by na-k-cl cotransport and not ca2+ influx at a key point in white matter development
Future meta-analyses should report excluded studies with justifications, incorporate comprehensive grey-literature and expert searches, preregister protocols, and explicitly propagate primary-study risk of bias into quantitative synthesis to strengthen the reliability and generalisability of conclusions
Existing research suggests that ER stress can lead to the upregulation of PERK, promoting islet -cell apoptosis, inhibiting insulin secretion, and inducing insulin resistance [120, 121]
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