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While Novo Nordisk has established first-mover advantages, Eli Lillys focus on triple-hormone agonism aims to outclass existing dual-action therapies on raw efficacy metrics

Across the entire orforglipron clinical development program, no hepatic safety signal has been identified

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In summary, we noted that muscarine alone and muscarine in the presence of drugs that activate cAMP-dependent protein kinases had a negative inotropic effect in the isolated human atrium