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Both the European Medicines Agency (EMA) and the Danish Medicines Agency are now reviewing semaglutides connection to NAION, and the FDA has launched a Sentinel study to investigate whether GLP-1 drugs increase the risk of sudden blindness

Strong evidence supports FDA-approved indications where applicable

The popularity of these medications created a surge in demand, which led to shortages of some GLP-1 receptor agonists that began in 2022

While GLP-1s are generally well tolerated and offer numerous health benefits from weight loss and better glucose control to a lower risk of cardiovascular disease research suggests they could increase the risk of certain serious eye conditions