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Oral dosing keeps plasma ascorbate below roughly 220 micromoles per liter (mol/L), whereas controlled IV infusion can safely **generate** pharmacologic concentrations of 2530 millimoles per liter (mmol/L)a finding documented by Mark Levines National Institutes of Health group in Vitamin C pharmacokinetics: implications for oral and intravenous use (Padayatty and colleagues, Annals of Internal Medicine, 2004)

However, nutrition interventions for PCOS can support regular menstrual function, regulate hormone levels, and improve other symptoms

Degener Neurol Neuromuscul Dis 12: 3159

For the entire group, the median vitamin B12 level before treatment was 328 (range, 244429) pmol/l, and 973 (range, 4761476) pmol/l after treatment