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303 Given the importance of ECM remodeling in CSC maintenance, therapeutic approaches targeting ECM-modifying enzymes such as matrix metalloproteinase inhibitors and lysyl oxidase inhibitors have been explored to impair CSC invasiveness and enhance treatment efficacy

doi: 10.1038/s41569-018-0108-7 177 ToitaR.KawanoT.MurataM.KangJ.-H.ToitaR.KawanoT.et al

136 A separate study conducted with mouse models of colon cancer indicated that alternate day fasting for 2 weeks triggered autophagy in cancer cells, which in turn downregulated CD73 expression