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Lean mass loss was reported for patients on semaglutide (~10% loss relative to baseline) and tirzepatide (~11% loss relative to baseline) during Phase III clinical trials, STEP-1, NCT03548935 and SURMOUNT-1, NCT04184622, respectively 61, 62

Moreover, olfactory interneuron precursors are chemoattracted by HGF from the sub-ventricular zone (SVZ) of the lateral ventricles, through the rostral migratory stream, to the olfactory bulb (Giacobini et al., 2007

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