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Meaningful fat loss typically becomes measurable by week two to week three, when combined appetite reduction and lower calorie intake create the conditions for sustainable weight change

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For some people, this adjustment can temporarily cause dips in blood sugar, which may leave them feeling weak or tired until their body adapts

Starting with FDA approvals of exenatide in 2005 and liraglutide (Victoza) in 2010, the field accelerated when liraglutide (Saxenda) gained an obesity indication (2014) and semaglutide (Ozempic) was approved for type 2 diabetes (2017)