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Asian J Surg 43(2):405416 Fagundes FL, Piffer GdM, Prico LL, Rodrigues VP, Hiruma-Lima CADos Santos RdC, (2020) Chrysin modulates genes related to inflammation, tissue remodeling, and cell proliferation in the gastric ulcer healing

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Furthermore, in colorectal cancer, ROS generated from inflammatory cells, such as neutrophils and macrophages, play a critical role in the progression of colorectal cancer by inducing DNA damage, promoting epithelial cell proliferation, and impairing apoptosis

For example, the combination of KD with metronomic cyclophosphamide significantly enhances antitumor effects, resulting in the regression of neuroblastoma tumors