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Our findings, using genetic models and isotope tracing, are consistent with a model in which CrAT produces acetylcarnitine from acetyl-CoA in mitochondria and then following export to the cytosol, it converts acetylcarnitine back to acetyl-CoA as an alternative to ACLY for two carbon transfer from mitochondria (Figure 7A)

Meanwhile, Nrf2 negatively regulates the activation of the NLRP3 inflammasome during the regulation of ROS

Freeze-thaw cycles may negatively affect certain peptides, so storage conditions should always follow available stability information for the specific compound

In conclusion, FOXO transcription factors function as versatile regulators of autophagy through the integration of nutrient, redox, and ER stress signals