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For example, while luminal or vascular administration of butyrate during an isolated perfused colon study increased GLP-1 and PYY secretion 93 , only vascular administration of acetate induced GLP-1 and PYY secretion, with luminal acetate inducing only GLP-1 secretion 93

Some researchers have proposed that concentrations above approximately 6 to 7 mol/L may already indicate suboptimal methylation and increased long term health risk

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