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Mood Support: Vitamin B12 plays a role in neurotransmitter production, helping to regulate mood and potentially alleviating symptoms of anxiety and depression
Clinical Trials: Impact of B12 Supplementation on Metabolites Below are four graphs showing the response to B12 supplementation of serum B12, holotranscobalamin, MMA, and homocysteine: Eight trials of predominantly older adults with at least mild deficiency (Dangour, 2015
Conditions include alcoholic liver disease, viral hepatitis, cirrhosis, and primary or metastatic liver cancer Renal dysfunction : Impaired kidney function reduces B12 elimination, causing accumulation even with normal intake Haematological conditions : Myeloproliferative neoplasms, chronic myeloid leukaemia, polycythaemia vera, and hypereosinophilic syndrome increase transcobalamin production, elevating total serum B12 Laboratory interference : Macro-B12 (immunoglobulin-bound B12) and assay interference can cause spuriously elevated results without true excess In clinical practice, unexplained hypercobalaminaemia should prompt investigation for underlying disease, particularly in patients without obvious supplementation history
It acts as a coenzyme in various metabolic pathways and is involved in DNA synthesis and red blood cell production
