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To complement this point, it's important to note that pro-inflammatory cytokine production can be upregulated when cells are exposed to pro-oxidant agents [33]

4.4 End-stage renal disease End-stage renal disease (ESRD) is characterized by a markedly higher likelihood of mortality resulting from cardiovascular events and infections

In 2024, the FDA issued a Drug Safety Communication regarding GLP-1 receptor agonists and suicidal ideation, noting that while they continue to monitor reports, a clear causal relationship has not been established

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