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(71) provided a comprehensive overview of various colon-targeted delivery systems, including resistant starch and natural biopolymers, emphasizing their shared mechanism of action: bypassing enzymatic degradation in the upper gastrointestinal tract and undergoing microbial enzyme-triggered breakdown in the colon to release bioactive compounds

Side effects like nausea, vomiting, or constipation occur more frequently with oral formulations than injections because the medication interacts directly with digestive tissues

Even when injected systemically into abdominal fat, the peptide appears to concentrate at injury sites

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